Really not likely, however, there is a rigorous demarcation between these features.
Plasmacytoid dendritic tissues
Approximately 1/3rd of most thymic DCs include plasmacytoid Dendritic tissue (pDCs). pDCs enter the thymus as a migratory inhabitants from peripheral web sites 56 , showing a detailed lineage partnership between peripheral and thymic pDCs. As peripheral pDCs serve a crucial purpose inside the safeguards against viral infections through their unique production of type we interferons 63 , the clear presence of a pDC society for the thymus had been suggested to reflect an equivalent innate immune work in a primary lymphoid body organ 55 .
Completely, these latest information existing a strong case for a contribution of pDCs to central endurance. Of notice, pDCs, in comparison to both subsets of cDCs, dont collect mTEC-derived antigens (J. Nedjic, T. Yamano, J. Derbinski, L.K. and B.K., unpublished findings), showing which they may test self antigens in periphery after which a€?freezea€™ their antigen luggage. Read more